NEISSERIA-MENINGITIDIS AND NEISSERIA-GONORRHOEAE BACTEREMIA ASSOCIATED WITH C6, C7, OR C8 DEFICIENCY

被引：251

作者：

PETERSEN, BH

LEE, TJ

SNYDERMAN, R

BROOKS, GF

机构：

[1] ELI LILLY & CO, LILLY LABS CLIN RES, INDIANAPOLIS, IN 46206 USA

[2] UNIV N CAROLINA, SCH MED, DEPT MED, DIV INFECT DIS & IMMUNOL, CHAPEL HILL, NC 27514 USA

[3] DUKE UNIV, MED CTR, DEPT MED, DIV RHEUMAT & GENET DISORDERS, DURHAM, NC 27706 USA

[4] UNIV CALIF SAN FRANCISCO, DEPT MED, SAN FRANCISCO, CA 94143 USA

[5] UNIV CALIF SAN FRANCISCO, DEPT LAB MED, SAN FRANCISCO, CA 94143 USA

来源：

ANNALS OF INTERNAL MEDICINE | 1979年 / 90卷 / 06期

关键词：

D O I：

10.7326/0003-4819-90-6-917

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We summarize data from 24 previously described or newly diagnosed cases of homozygous deficiency of the sixth, seventh, or eighth components of complement. Thirteen of 24 patients had at least one episode, and usually two or more episodes of Neisseria meningitidis or Neisseria gonorrhoeae bacteremia, or both. Deficiency of C6, C7, or C8 is a meaningful risk factor for repeated neisserial bacteremia; conversely, hemolytic complement studies are indicated in patients who develop recurrent neisserial infections. When a person with C6, C7, or C8 deficiency is identified, family members should also be studied.

引用

页码：917 / 920

页数：4

共 37 条

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