Leptomeningeal Carcinomatosis from Pancreatic Cancer Associated With Germline BRCA Mutations: Case Reports and Review of the Literature

Leptomeningeal carcinomatosis from pancreatic cancer is a rare finding thought to occur late in the natural history of the disease. Here we present two cases of leptomeningeal carcinomatosis from BRCA mutation-associated pancreatic cancer including one patient in whom it developed during treatment with a PARP-inhibitor. We review the literature and discuss the possibility that BRCA-associated pancreatic cancer may have a natural history that is distinct from sporadic cases.