BIOCHEMICAL EFFECTS OF ACRYLONITRILE ON RAT-LIVER, AS INFLUENCED BY VARIOUS PRETREATMENTS OF ANIMALS

被引：6

作者：

DUVERGERVANBOGAERT, M ^{[1
]}

LAMBOTTEVANDEPAER, M ^{[1
]}

NOEL, G ^{[1
]}

ROBERFROID, M ^{[1
]}

MERCIER, M ^{[1
]}

机构：

[1] CATHOLIC UNIV LOUVAIN,SCH PHARM,BIOTOXICOL LAB,B-1200 BRUSSELS,BELGIUM

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 83卷 / 03期

关键词：

D O I：

10.1016/0006-291X(78)91511-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acrylonitrile is extensively used in the synthesis of plastics, some of which are used for the packaging of food and beverage. A single dose of AN causes an increase in serum lactate and sorbitol dehydrogenase levels, as well as a decrease of liver cytochrome P-450 content and microsomal aldrin oxide synthetase activity. Those effects are prevented by pretreatments of the animals with either inducers of the mixed function oxidases or L-cysteine; diethylmaleate pretreatment enhances the increase of the soluble enzyme levels. © 1978.

引用

页码：1117 / 1124

页数：8

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