This study assessed whether stress, social support, and interpersonal problem-solving appraisal/skills were predictive of level of suicidality within a chronic suicidal college sample. Stepwise regression analyses were used to assess whether stress, social support, and problem-solving were independently predictive of severity of suicide ideation. In addition, hierarchical regression analyses were used to test the mediational nature of social support and problem-solving in the stress-suicidality relationship. Problem-solving confidence was found to be a significant predictor of severity of suicide ideation. In addition, both perceived problem-solving skills and social support mediated the relationship between stress and level of suicide ideation. However, only one of the two perceived problem-solving skills interactions was in the expected direction. This study provided support for the importance of problem-solving confidence and the interaction of stress and social support in the prediction of suicide seventy. Unlike previous studies, this study did not find problem-solving skills/deficits to mediate the stress-suicidality relationship.