INDUCTION OF NITRIC-OXIDE SYNTHASE IN DEMYELINATING REGIONS OF MULTIPLE-SCLEROSIS BRAINS

被引：507

作者：

BO, L

DAWSON, TM

WESSELINGH, S

MORK, S

CHOI, S

KONG, PA

HANLEY, D

TRAPP, BD

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

[3] UNIV BERGEN,HAUKELAND HOSP,DEPT PATHOL,N-5021 BERGEN,NORWAY

来源：

ANNALS OF NEUROLOGY | 1994年 / 36卷 / 05期

关键词：

D O I：

10.1002/ana.410360515

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The amount of messenger RNA encoding human inducible nitric oxide synthase and the presence and distribution of NADPH diaphorase were determined in tissue sections from multiple sclerosis (MS) and control brains. Levels of human nitric oxide synthase messenger RNA were markedly elevated in MS brains when compared to normal control brains. NADPH diaphorase activity, a histochemical stain reflecting nitric oxide synthase catalytic activity, was detected in reactive astrocytes in active demyelinating MS lesions and at the edge of chronic active demyelinating lesions. Control brains did not contain NADPH diaphorase-positive astrocytes. These results implicate the free radical nitric oxide in the pathogenesis of demyelinating MS lesions.

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页码：778 / 786

页数：9

相关论文

共 46 条

[1] PATHOLOGY OF MULTIPLE-SCLEROSIS - PROGRESSION OF LESION [J].

ADAMS, CWM .

BRITISH MEDICAL BULLETIN, 1977, 33 (01) :15-+

[2] DETECTION OF MHC CLASS-II ANTIGENS ON MACROPHAGES AND MICROGLIA, BUT NOT ON ASTROCYTES AND ENDOTHELIA IN ACTIVE MULTIPLE-SCLEROSIS LESIONS [J].

BO, L ;

MORK, S ;

KONG, PA ;

NYLAND, H ;

PARDO, CA ;

TRAPP, BD .

JOURNAL OF NEUROIMMUNOLOGY, 1994, 51 (02) :135-146

[3] NITRIC-OXIDE SYNTHASE PROTEIN AND MESSENGER-RNA ARE DISCRETELY LOCALIZED IN NEURONAL POPULATIONS OF THE MAMMALIAN CNS TOGETHER WITH NADPH DIAPHORASE [J].

BREDT, DS ;

GLATT, CE ;

HWANG, PM ;

FOTUHI, M ;

DAWSON, TM ;

SNYDER, SH .

NEURON, 1991, 7 (04) :615-624

[4] NITRIC-OXIDE - A PHYSIOLOGICAL MESSENGER MOLECULE [J].

BREDT, DS ;

SNYDER, SH .

ANNUAL REVIEW OF BIOCHEMISTRY, 1994, 63 :175-195

[5] CLONING, CHARACTERIZATION, AND EXPRESSION OF A CDNA-ENCODING AN INDUCIBLE NITRIC-OXIDE SYNTHASE FROM THE HUMAN CHONDROCYTE [J].

CHARLES, IG ;

PALMER, RMJ ;

HICKERY, MS ;

BAYLISS, MT ;

CHUBB, AP ;

HALL, VS ;

MOSS, DW ;

MONCADA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) :11419-11423

[6] A NOVEL NEURONAL MESSENGER MOLECULE IN BRAIN - THE FREE-RADICAL, NITRIC-OXIDE [J].

DAWSON, TM ;

DAWSON, VL ;

SNYDER, SH .

ANNALS OF NEUROLOGY, 1992, 32 (03) :297-311

[7] NITRIC-OXIDE SYNTHASE AND NEURONAL NADPH DIAPHORASE ARE IDENTICAL IN BRAIN AND PERIPHERAL-TISSUES [J].

DAWSON, TM ;

BREDT, DS ;

FOTUHI, M ;

HWANG, PM ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7797-7801

[8] MICROGLIA AND CYTOKINES IN NEUROLOGICAL DISEASE, WITH SPECIAL REFERENCE TO AIDS AND ALZHEIMERS-DISEASE [J].

DICKSON, DW ;

LEE, SC ;

MATTIACE, LA ;

YEN, SHC ;

BROSNAN, C .

GLIA, 1993, 7 (01) :75-83

[9] INDUCTION OF CALCIUM-INDEPENDENT NITRIC-OXIDE SYNTHASE ACTIVITY IN PRIMARY RAT GLIAL CULTURES [J].

GALEA, E ;

FEINSTEIN, DL ;

REIS, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) :10945-10949

[10] MOLECULAR-CLONING AND EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE FROM HUMAN HEPATOCYTES [J].

GELLER, DA ;

LOWENSTEIN, CJ ;

SHAPIRO, RA ;

NUSSLER, AK ;

DISILVIO, M ;

WANG, SC ;

NAKAYAMA, DK ;

SIMMONS, RL ;

SNYDER, SH ;

BILLIAR, TR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3491-3495

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