CALCIUM AGONISTS AND ANTAGONISTS OF THE DIHYDROPYRIDINE TYPE - EFFECT ON NICOTINE-INDUCED ANTINOCICEPTION AND HYPOMOTILITY

被引:31
作者
DAMAJ, MI [1 ]
MARTIN, BR [1 ]
机构
[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,RICHMOND,VA 23298
关键词
CALCIUM ANTAGONISTS; BAYK-8644; NICOTINE; ANTINOCICEPTION; MICE;
D O I
10.1016/0376-8716(93)90024-K
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
The influence of a calcium agonist (BAYK 8644) and several calcium channel blockers on nicotine-induced antinociception was investigated in mice. The effect of nicotine was sharply increased by BAYK 8644. This potentitation by BAYK 8644 was blocked by pretreating the animals with nifedipine at 2 and 10 mg/kg. The calcium channel antagonigts, nifedipine and nimodipine at doses that had no effect on tail-flick time, reduced significantly the antinociception induced by nicotine (1.5 mg/kg, s.c.). However, the effect of verapamil on nicotine was not significant. These results indicate that DHP calcium channels (type L-channel) play a role in some of the pharmacological effects of nicotine, particularly, locomotor activity and antinociception.
引用
收藏
页码:73 / 79
页数:7
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