ESTIMATION OF PERMANENCE TIME, EXIT TIME, DILUTION FACTOR, AND STEADY-STATE VOLUME OF DISTRIBUTION

被引：27
作者：
MORDENTI, J
RESCIGNO, A
机构：
[1] Department of Pharmacokinetics, Genentech Inc., South San Francisco, California, 94080
[2] School of Pharmacy, University of Parma, Parma
来源：
PHARMACEUTICAL RESEARCH | 1992年 / 9卷 / 01期
关键词：
ALLOMETRIC SCALING; COMPARTMENTAL AND NONCOMPARTMENTAL PHARMACOKINETICS; DILUTION FACTOR; EXIT TIME; PERMANENCE TIME; PROTEIN THERAPEUTICS; RECOMBINANT HUMAN CD4-IMMUNOGLOBULIN-G (RCD4-IGG); STEADY-STATE VOLUME; TRACERS;
D O I：
10.1023/A:1018915307554
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
General solutions for exit time, permanence time, dilution factor, and volume of distribution at steady state are derived for compartmental and noncompartmental systems. These derivations require that the systems are linear and state-determined. Unique values for these parameters cannot be determined when the site of elimination is not known; in this case the parameters can be defined by a range. Interpretation of this range and its significance and use in clinical situations are illustrated with two examples.
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页码：17 / 25
页数：9
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