Current insights on exercise-induced bronchoconstriction pathogenesis in asthmatic patients

被引：0

作者：

Zietkowski, Ziemowit ^{[1
]}

Lukaszyk, Mateusz ^{[2
]}

Zietkowska, Elzbieta ^{[3
,4
]}

Bodzenta-Lukaszyk, Anna ^{[1
]}

机构：

[1] Uniwersytet Med & Bialymstoku, Klin Alergol & Chorob Wewnetrznych, Ul Sklodowskiej 24A, PL-15276 Bialystok, Poland

[2] Uniwersytet Med & Bialymstoku, Studium Doktoranckie, Bialystok, Poland

[3] Uniwersytecki Szpital Klin Bialymstoku, Bialystok, Poland

[4] Inst Med & Lomzy, Panstwowa Wyzsza Szkola Informat Przedsiebiorc Lo, Lomzy, Poland

来源：

ALERGIA ASTMA IMMUNOLOGIA | 2014年 / 19卷 / 03期

关键词：

exercise induced bronchoconstriction; asthma; pathogenesis; exercise;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cough, wheezing and dyspnea followed by physical activity are the syndromes as well as control parameters typical of asthma. Strenuous exercise evokes a decrease in temperature of the air passing through lower airways, desiccating the airway's mucus membrane and increasing it's osmolarity leading to mast cells degranulation, mediator release, bronchial smooth muscles constriction and epithelium damage. The latest data confirms the indubitable correlation between the ongoing inflammatory process characteristic of asthma and the airway epithelium, platelet activation and an increase in pro-inflammatory mediator expression, which should determine the therapeutic proceedings.

引用

页码：126 / 129

页数：4

共 34 条

[1] The mechanism of exercise-induced asthma is ... [J].

Anderson, SD ;

Daviskas, E .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 106 (03) :453-459

[2] Exercise Increases Exhaled Breath Condensate Cysteinyl Leukotriene Concentration in Asthmatic Patients [J].

Bikov, Andras ;

Gajdocsi, Reka ;

Huszar, Eva ;

Szili, Balazs ;

Lazar, Zsofia ;

Antus, Balazs ;

Losonczy, Gyoergy ;

Horvath, Ildiko .

JOURNAL OF ASTHMA, 2010, 47 (09) :1057-1062

[3] Adenosine level in exhaled breath increases during exercise-induced bronchoconstriction [J].

Csoma, Z ;

Huszár, É ;

Vizi, É ;

Vass, G ;

Szabó, Z ;

Herjavecz, I ;

Kollai, M ;

Horváth, I .

EUROPEAN RESPIRATORY JOURNAL, 2005, 25 (05) :873-878

[4] ROLE OF RESPIRATORY HEAT-EXCHANGE IN PRODUCTION OF EXERCISE-INDUCED ASTHMA [J].

DEAL, EC ;

MCFADDEN, ER ;

INGRAM, RH ;

STRAUSS, RH ;

JAEGER, JJ .

JOURNAL OF APPLIED PHYSIOLOGY, 1979, 46 (03) :467-475

[5] Endothelin-1 (ET-1) decreases human bronchial epithelial cell migration and proliferation: Implications for airway remodeling in asthma [J].

Dosanjh, A ;

Zuraw, B .

JOURNAL OF ASTHMA, 2003, 40 (08) :883-886

[6] Neurokinins modulate hyperventilation-induced bronchoconstriction in canine peripheral airways [J].

Freed, AN ;

McCulloch, S ;

Meyers, T ;

Suzuki, R .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 167 (08) :1102-1108

[7] Endothelin stimulates transforming growth factor-β1 and collagen synthesis in stellate cells from control but not cirrhotic rat liver [J].

Gandhi, CR ;

Kuddus, RH ;

Uemura, T ;

Rao, AS .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 406 (03) :311-318

[8]

GINA, 2006, 2006 NHLBIWHO

[9] Endothelins and asthma [J].

Goldie, RG ;

Henry, PJ .

LIFE SCIENCES, 1999, 65 (01) :1-15

[10] Relationship between levels of secreted phospholipase A2 groups IIA and X in the airways and asthma severity [J].

Hallstrand, T. S. ;

Lai, Y. ;

Ni, Z. ;

Oslund, R. C. ;

Henderson, W. R., Jr. ;

Gelb, M. H. ;

Wenzel, S. E. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2011, 41 (06) :801-810

← 1 2 3 4 →