A SYNTHETIC METHOD FOR UNSYMMETRICAL DISULFIDES OF CYSTEINE - THE BIS-CYSTEINE DISULFIDE OF MESO-2,3-DIMERCAPTOSUCCINIC ACID

被引：6
作者：
POLT, R
LI, YS
FERNANDO, Q
RIVERA, M
机构：
[1] Department of Chemistry, Univesity of Arizona, Tucson
来源：
TETRAHEDRON LETTERS | 1992年 / 33卷 / 21期
关键词：
D O I：
10.1016/S0040-4039(00)79572-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine.
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页码：2961 / 2964
页数：4
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