WATER-SOLUBLE CALIXARENE AS THE 1ST MAN-MADE CATALYST FOR REGIOSELECTIVE CLEAVAGE OF RIBONUCLEOSIDE 2',3'-CYCLIC PHOSPHATE

被引：32

作者：

KOMIYAMA, M ^{[1
]}

ISAKA, K ^{[1
]}

SHINKAI, S ^{[1
]}

机构：

[1] KYUSHU UNIV, FAC ENGN, DEPT ORGAN SYNTH, FUKUOKA 812, JAPAN

来源：

CHEMISTRY LETTERS | 1991年 / 06期

关键词：

D O I：

10.1246/cl.1991.937

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The P-O (2') bond of cytidine 2',3'-cyclic phosphate, an intermediate in RNA hydrolysis, is regioselectively cleaved at pH 2 by use of water-soluble calix[4]arene-5,11,17,23-tetra-sulfonate. This is the first totally man-made mimic for the regioselective catalysis of ribonuclease.

引用

页码：937 / 940

页数：4

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