OPTIMIZATION OF NMR AND HPLC CONDITIONS FOR LC-NMR

被引：28
作者：
GRIFFITHS, L
机构：
[1] Pharmaceutical Department, ZENECA Pharmaceuticals, Hurdsfield Industrial Estate, Macclesfield
来源：
ANALYTICAL CHEMISTRY | 1995年 / 67卷 / 22期
关键词：
D O I：
10.1021/ac00118a010
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The NMR sensitivity was recognized as the major issue in the optimization of the coupled HPLC-NMR experiment, Each of the relevant interactions between HPLC parameters and NMR parameters has been examined in detail, such that workers should be able to design a strategy to optimize their own experiments.
引用
收藏
页码：4091 / 4095
页数：5
相关论文
共 11 条
[1]   CONTINUOUS-FLOW NUCLEAR MAGNETIC-RESONANCE [J].
ALBERT, K ;
NIEDER, M ;
BAYER, E .
JOURNAL OF CHROMATOGRAPHY, 1985, 346 (OCT) :17-24
[2]   HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY - NUCLEAR MAGNETIC-RESONANCE ONLINE COUPLING [J].
ALBERT, K ;
BAYER, E .
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 1988, 7 (08) :288-293
[3]  
ALBERT K, 1989, J CHROMATOGR, V436, P355
[4]   A SPATIALLY SELECTIVE COMPOSITE 90-DEGREES RADIOFREQUENCY PULSE [J].
BAX, A .
JOURNAL OF MAGNETIC RESONANCE, 1985, 65 (01) :142-145
[5]   ONLINE COUPLING OF LIQUID-CHROMATOGRAPHY AND HIGH-FIELD NUCLEAR MAGNETIC-RESONANCE SPECTROMETRY [J].
BAYER, E ;
ALBERT, K ;
NIEDER, M ;
GROM, E ;
WOLFF, G ;
RINDLISBACHER, M .
ANALYTICAL CHEMISTRY, 1982, 54 (11) :1747-1750
[6]   ONLINE COUPLING OF HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND NUCLEAR MAGNETIC-RESONANCE [J].
BAYER, E ;
ALBERT, K ;
NIEDER, M ;
GROM, E .
JOURNAL OF CHROMATOGRAPHY, 1979, 186 (DEC) :497-507
[7]   H-1-NMR - A NEW DETECTOR FOR LIQUID-CHROMATOGRAPHY [J].
DORN, HC .
ANALYTICAL CHEMISTRY, 1984, 56 (06) :A747-&
[8]   APPLICATION OF FOURIER TRANSFORM SPECTROSCOPY TO MAGNETIC RESONANCE [J].
ERNST, RR ;
ANDERSON, WA .
REVIEW OF SCIENTIFIC INSTRUMENTS, 1966, 37 (01) :93-+
[9]  
Giddings C., 1991, UNIFIED SEPARATION S, P101
[10]  
Jones D.W., 1976, ADV MAGN OPT RESON, DOI [10.1016/B978-0-12-025508-5.50008-6, DOI 10.1016/B978-0-12-025508-5.50008-6]
12