ARYLHYDROXAMIC ACID N,O-ACYLTRANSFERASE - APPARENT SUICIDE INACTIVATION BY CARCINOGENIC N-ARYLHYDROXAMIC ACIDS

被引：21
作者：
BANKS, RB
HANNA, PE
机构：
[1] UNIV MINNESOTA,DEPT MED CHEM,MINNEAPOLIS,MN 55455
[2] UNIV MINNESOTA,DEPT PHARMACOL,MINNEAPOLIS,MN 55455
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 04期
关键词：
D O I：
10.1016/0006-291X(79)91225-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Carcinogenic arylhydroxamic acids (N-hydroxy-2-acetylamino-fluorene, N-hydroxy-4-acetylaminobiphenyl, and trans-N-hydroxy-4-acetyl-aminostilbene) are irreversible inhibitors of rat and hamster hepatic N,O-acyltransferase. The kinetic characteristics of this inhibition are consistent with suicide inactivation of the enzyme. This finding appears to be the first example of carcinogens serving as suicide substrates for an enzyme system which is responsible for their bioactivation. © 1979.
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页码：1423 / 1429
页数：7
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