ELECTROCHEMICAL STUDIES OF THE OXIDATION PATHWAYS OF APOMORPHINE

被引：43

作者：

CHENG, HY ^{[1
]}

STROPE, E ^{[1
]}

ADAMS, RN ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT CHEM,LAWRENCE,KS 66045

来源：

ANALYTICAL CHEMISTRY | 1979年 / 51卷 / 13期

关键词：

D O I：

10.1021/ac50049a042

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The oxidative reaction mechanisms of apomorphine in aqueous buffer are reported, based on electrochemical data and product analysis. In the absence of strong nucleophiles, an irreversible chemical reaction follows the initial 2e-/2H+ oxidation of apomorphine and eventually produces a new redox couple. This new redox couple adsorbs irreversibly on the Nujol-carbon paste electrode surface and exhibits properties of electrocatalysis on the oxidation of ascorbic acid. In the presence of excess glutathione, a strong nucleophile, other reactions predominate. © 1979, American Chemical Society. All rights reserved.

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页码：2243 / 2246

页数：4

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