INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II GENE-EXPRESSION IN BALB/C MOUSE-LIVER DURING POSTNATAL-DEVELOPMENT

被引：0
作者：
SINGH, JS
RALL, LB
STYNE, DM
机构：
[1] UNIV CALIF DAVIS,SCH MED,DEPT PEDIAT,MSIA ROOM 1134,DAVIS,CA 95616
[2] CHIRON CORP,EMERYVILLE,CA
来源：
BIOLOGY OF THE NEONATE | 1991年 / 60卷 / 01期
关键词：
GROWTH FACTORS; NEONATE; WEANING; PUBERTY;
D O I：
暂无
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
We studied the developmental shift from IGF-II to IGF-I mRNA synthesis in Balb/C mouse liver. IGF-I mRNA levels were low at birth, increased with age to peak at weaning, and IGF-I gene expression again increased during puberty. IGF-II expression was high during early postnatal development, but became nondetectable at weaning. Thus in early life there is a reciprocal relationship of rising IGF-I and falling IGF-II mRNA. Northern analysis revealed four IGF-mRNA transcripts ranging from 1.1-7.0 kb, with the 1.1 kb being the most prominent. Five IGF-II transcripts ranging from 1.7-4.0 kb were found, with the 4,0 kb being the most prominent. The pattern of Serum IGF-I and IGF-II values paralleled liver IGF-I and IGF-II mRNA levels.
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页码：7 / 18
页数：12
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