NMDA RECEPTOR BLOCKADE INHIBITS GLUTAMATE-INDUCED KINDLING OF THE RAT AMYGDALA

被引：55
作者：
CROUCHER, MJ
BRADFORD, HF
机构：
[1] Department of Biochemistry, Imperial College of Science, Technology and Medicine, London
来源：
BRAIN RESEARCH | 1990年 / 506卷 / 02期
基金：
英国医学研究理事会;
关键词：
2-Amino-7-phosphonoheptanoic acid; Epilepsy; Excitatory amino acid; Glutamate; Kindling; Seizure;
D O I：
10.1016/0006-8993(90)91279-P
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Full limbic seizures were kindled in rats by repeated, bi-daily microinjections of glutamate (1.5 μmol) into the basolateral amygdala. Co-administration of the N-methyl-d-aspartate (NMDA) receptor antagonist 2-amino-7-phosphonoheptanoic acid with the glutamate, prevented the development of both electroencephalographic and motor signs of the kindling response. These results indicate an important functional role for NMDA receptors in the development of excitatory amino acid-induced kindling. © 1990.
引用
收藏
页码：349 / 352
页数：4
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