THE P53 TUMOR SUPPRESSOR GENE

被引：3928
作者：
LEVINE, AJ
MOMAND, J
FINLAY, CA
机构：
[1] Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton
来源：
NATURE | 1991年 / 351卷 / 6326期
关键词：
D O I：
10.1038/351453a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors. Chief among the negative regulators is the p53 protein. Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of DNA tumour viruses, can lead to cancer. These mutations seem to be the most common genetic change in human cancers.
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页码：453 / 456
页数：4
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