PHASE-II STUDY OF DEOXYDOXORUBICIN IN PREVIOUSLY UNTREATED METASTATIC BREAST-CANCER

被引:3
作者
MARTINO, S [1 ]
SAMAL, BA [1 ]
REDMAN, B [1 ]
FLAHERTY, L [1 ]
KRAUT, M [1 ]
SIMON, M [1 ]
VALDIVIESO, M [1 ]
机构
[1] WAYNE STATE UNIV,GRACE HOSP,DEPT INTERNAL MED,DIV HEMATOL & ONCOL,DETROIT,MI 48202
关键词
BREAST CANCER; CHEMOTHERAPY; DEOXYDOXORUBICIN; PHASE-II TRIAL;
D O I
10.1007/BF01806294
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
With the objective of identifying new chemotherapeutic agents active against breast cancer, we administered the phase II agent deoxydoxorubicin (DxDx) to 25 patients who had received no prior chemotherapy for their metastatic breast cancer. A dose of 30-35 mg/M2 given at 3 week intervals resulted in a response rate of 12%. The patients were subsequently treated with a combination of 5-fluorouracil, methotrexate, vincristine, cyclophosphamide, and prednisone. A response rate of 38% was achieved with this combination as second line therapy. Toxicity of DxDx was predominately hematopoietic. One patient developed congestive heart failure. Median survival from onset of treatment with DxDx was 39 weeks. DxDx appears to be minimally active against metastatic breast cancer. Whether the administration of phase II agents as first line therapy offers an avantage in the overall management of metastatic cancer, needs further evaluation.
引用
收藏
页码:139 / 143
页数:5
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