ENDOTHELIN AND PDGF DO NOT STIMULATE PERIPHERAL-BLOOD MONOCYTE CHEMOTAXIS, ADHESION TO ENDOTHELIUM, AND SUPEROXIDE PRODUCTION

被引：32

作者：

BATH, PMW ^{[1
]}

MAYSTON, SA ^{[1
]}

MARTIN, JF ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

EXPERIMENTAL CELL RESEARCH | 1990年 / 187卷 / 02期

关键词：

D O I：

10.1016/0014-4827(90)90102-G

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endothelin is a potent vasoconstrictory endothelial-derived peptide which can induce smooth muscle proliferation and therefore may be proatherogenic. Platelet-derived growth factor is also a potent mitogenic vasoconstrictory protein which is proatherogenic. We report that neither endothelin nor PDGF stimulate superoxide production, or monocyte adhesion to porcine aortic endothelial cell monolayers; additionally endothelin is not a chemoattractant factor for monocytes. If endothelin and PDGF are important in atherogenesis it is unlikely that a monocyte response to these mediators is involved. © 1990.

引用

页码：339 / 342

页数：4

共 23 条

[1]

ARMITAGE P, 1987, STATISTICAL METHODS

[2] MONOCYTE-LYMPHOCYTE DISCRIMINATION IN A NEW MICROTITRE-BASED ADHESION ASSAY [J].