ETHANOL INHIBITION OF VINYL-CHLORIDE METABOLISM IN ISOLATED RAT HEPATOCYTES

被引：14

作者：

HULTMARK, D ^{[1
]}

SUNDH, K ^{[1
]}

JOHANSSON, L ^{[1
]}

ARRHENIUS, E ^{[1
]}

机构：

[1] UNIV STOCKHOLM,WALLENBERG LAB,DIV CELLULAR TOXICOL,ENVIRONM TOXICOL UNIT,S-10691 STOCKHOLM,SWEDEN

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1979年 / 25卷 / 01期

关键词：

D O I：

10.1016/0009-2797(79)90064-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Isolated rat liver cells convert [14C]vinyl chloride into non-volatile metabolites. This metabolism is not increased by in vivo pretreatment with phenobarbital. It is sensitive to inhibition by ethanol, which at a concentration of 4 mM inhibits vinyl chloride metabolism to 50% in hepatocyte suspensions. The metabolic activity is NADPH-dependent and is localized in the microsomal fraction of the liver. The enzyme is also strongly inhibited by tetrahydrofuran, indicating that it could be identical to an ethanol-inducible cytochrome P-450 described in the literature [1]. © 1979.

引用

页码：1 / 6

页数：6

共 20 条

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LOWRY OH, 1951, J BIOL CHEM, V193, P265

[12]

LU AYH, 1976, FED PROC, V35, P2460

[13] MUTAGENICITY OF VINYL-CHLORIDE, CHLOROETHYLENEOXIDE, CHLOROACETALDEHYDE AND CHLOROETHANOL [J].