Some Effects of Statins on Ischemic Stroke: A Review

被引：0
作者：
Hashemi, Kobra [1 ]
机构：
[1] Hormozgan Univ Med Sci, Student Res Comm, Bandar Abbas, Iran
来源：
RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES | 2015年 / 6卷 / 02期
关键词：
statins; ischemia; stroke;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Stroke is widely effect on health quality around the world. High incidence of stroke, make this disease as a problem for health providers. Recently, some advantages of statins about prophylaxis from stroke incidence and neuroprotective effects are discussed. Beyond the lipid lowering effect of statins, these drugs have other benefits for patients that have risk factors of stroke or chance of recurrent stroke. This review will discuss the some advantages of statins application in stroke patients. We summarized the common statins mediated mechanisms in ischemic stroke patients such as anti-oxidative effect, effect on Matrix metalloproteases, Pathway of eNOS-mediated, nitric oxide, blood pressure and atherosclerosis, and also lipid lowering levels.
引用
收藏
页码：1341 / 1346
页数：6
相关论文
共 23 条
[1]   Lipid lowering and recurrent stroke: another stroke paradox? [J].
Amarenco, P .
EUROPEAN HEART JOURNAL, 2005, 26 (18) :1818-1819
[2]  
Amarenco P, 2006, J VASC SURG, V355, P1374, DOI 10.1016/j.jvs.2006.10.008
[3]   High-density lipoprotein-cholesterol and risk of stroke and carotid atherosclerosis: A systematic review [J].
Amarenco, Pierre ;
Labreuche, Julien ;
Touboul, Pierre-Jean .
ATHEROSCLEROSIS, 2008, 196 (02) :489-496
[4]   Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention [J].
Amarenco, Pierre ;
Labreuche, Julien .
LANCET NEUROLOGY, 2009, 8 (05) :453-463
[5]   Baseline blood pressure, low- and high-density lipoproteins, and triglycerides and the risk of vascular events in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial [J].
Amarenco, Pierre ;
Goldstein, Larry B. ;
Callahan, Alfred, III ;
Sillesen, Henrik ;
Hennerici, Michael G. ;
O'Neill, Blair J. ;
Rudolph, Amy E. ;
Simunovic, Lisa ;
Zivin, Justin A. ;
Welch, K. M. A. .
ATHEROSCLEROSIS, 2009, 204 (02) :515-520
[6]  
American Heart Association, EC COST CARD DIS
[7]  
American Heart Association, 2014, HEART DIS STROK STAT
[8]  
[Anonymous], 2012, TYP STROK AM STROK A
[9]  
[Anonymous], 2012, TYP STROK
[10]   The Greater Cincinnati Northern Kentucky Stroke Study - Preliminary first-ever and total incidence rates of stroke among blacks [J].
Broderick, J ;
Brott, T ;
Kothari, R ;
Miller, R ;
Khoury, J ;
Pancioli, A ;
Gebel, J ;
Mills, D ;
Minneci, L ;
Shukla, R .
STROKE, 1998, 29 (02) :415-421
123