Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases

被引：83

作者：

Al-Majid, Ahmed ^{[1
]}

Alassiri, Saeed ^{[2
,3
]}

Rathnayake, Nilminie ^{[4
]}

Tervahartiala, Taina ^{[2
,3
]}

Gieselmann, Dirk-Rolf ^{[5
,6
]}

Sorsa, Timo ^{[2
,3
,4
]}

机构：

[1] Univ Zurich, Ctr Dent Med, Clin Prevent Dent Periodontol & Cariol, Zurich, Switzerland

[2] Univ Helsinki, Dept Oral & Maxillofacial Dis, Helsinki, Finland

[3] Helsinki Univ Hosp, Helsinki, Finland

[4] Karolinska Inst, Div Periodontol, Dept Dent Med, Stockholm, Sweden

[5] Dentognostics GmbH, Inst Mol Diagnost, Solingen, Germany

[6] Dentognostics GmbH, Inst Mol Diagnost, Jena, Germany

来源：

INTERNATIONAL JOURNAL OF DENTISTRY | 2018年 / 2018卷

关键词：

D O I：

10.1155/2018/7891323

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Levels of and especially the degree of activation of matrix metalloproteinase (MMP-8) in oral fluids (i.e., saliva, mouth rinse, gingival crevicular fluid (GCF) and peri-implantitis sulcular fluid (PISF)) increase to pathologically elevated levels in the periodontal and peri-implant diseases. This study aimed at collecting and collating data from previously published studies and determining whether active MMP-8 (aMMP-8) could serve as a biomarker for the diagnosis and prevention of periodontal and peri-implant diseases. The literature search identified a total of 284 articles. Out of 284 articles, 61 articles were found to be relevant. Data obtained from the selected studies were combined, and it indicated that aMMP-8 in oral fluids exerts the strong potential to serve as a useful adjunctive diagnostic and preventive biotechnological tool in periodontal and peri-implant diseases. aMMP-8 can be used alone or in combination with other proinflammatory and/or microbiological biomarkers.

引用

页数：27

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