Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases

被引：78
作者：
Al-Majid, Ahmed [1 ]
Alassiri, Saeed [2 ,3 ]
Rathnayake, Nilminie [4 ]
Tervahartiala, Taina [2 ,3 ]
Gieselmann, Dirk-Rolf [5 ,6 ]
Sorsa, Timo [2 ,3 ,4 ]
机构：
[1] Univ Zurich, Ctr Dent Med, Clin Prevent Dent Periodontol & Cariol, Zurich, Switzerland
[2] Univ Helsinki, Dept Oral & Maxillofacial Dis, Helsinki, Finland
[3] Helsinki Univ Hosp, Helsinki, Finland
[4] Karolinska Inst, Div Periodontol, Dept Dent Med, Stockholm, Sweden
[5] Dentognostics GmbH, Inst Mol Diagnost, Solingen, Germany
[6] Dentognostics GmbH, Inst Mol Diagnost, Jena, Germany
来源：
INTERNATIONAL JOURNAL OF DENTISTRY | 2018年 / 2018卷
关键词：
D O I：
10.1155/2018/7891323
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Levels of and especially the degree of activation of matrix metalloproteinase (MMP-8) in oral fluids (i.e., saliva, mouth rinse, gingival crevicular fluid (GCF) and peri-implantitis sulcular fluid (PISF)) increase to pathologically elevated levels in the periodontal and peri-implant diseases. This study aimed at collecting and collating data from previously published studies and determining whether active MMP-8 (aMMP-8) could serve as a biomarker for the diagnosis and prevention of periodontal and peri-implant diseases. The literature search identified a total of 284 articles. Out of 284 articles, 61 articles were found to be relevant. Data obtained from the selected studies were combined, and it indicated that aMMP-8 in oral fluids exerts the strong potential to serve as a useful adjunctive diagnostic and preventive biotechnological tool in periodontal and peri-implant diseases. aMMP-8 can be used alone or in combination with other proinflammatory and/or microbiological biomarkers.
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页数：27
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