ACTIVATED MACROPHAGES DIGEST THE EXTRACELLULAR MATRIX PROTEINS PRODUCED BY CULTURED-CELLS

被引：45

作者：

JONES, PA ^{[1
]}

SCOTTBURDEN, T ^{[1
]}

机构：

[1] MRC,MOLEC & CELLULAR CARDIOL UNIT,TYGERBERG 7505,SOUTH AFRICA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-291X(79)90383-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activated mouse peritoneal macrophages were cultured directly on the extracellular matrix proteins produced by smooth muscle cells in vitro. The breakdown of the connective tissue proteins to the level of amino acids was followed by observing the release of radioactivity from matrices labelled with [3H]proline. These studies showed that macrophages produce enzymes capable of digesting the matrix and indicated a major role for the macrophage plasminogen activator in this digestion. © 1979.

引用

页码：71 / 77

页数：7

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