PITUITARY-GONADAL RESPONSE TO THE GONADOTROPIN-RELEASING HORMONE ANALOG D-SER(TBU)6-DES GLY10-LHRH-ETHYLAMIDE IN NORMAL MEN

被引：7
|
作者：
HEATH, M
SCANLON, MF
MORA, B
SNOW, MH
GOMEZPAN, A
WATSON, MJ
MULLIGAN, F
HALL, R
机构：
[1] ROYAL VICTORIA INFIRM,DEPT MED,ENDOCRINE UNIT,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND
[2] ROYAL VICTORIA INFIRM,DEPT CLIN BIOCHEM,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND
来源：
CLINICAL ENDOCRINOLOGY | 1979年 / 10卷 / 03期
关键词：
D O I：
10.1111/j.1365-2265.1979.tb02084.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We have studied the dose‐response characteristics of the LHRH analogue D‐Ser (TBU)6‐Des Gly10‐LHRH‐ethylamide administered subcutaneously to five normal male volunteers. The relative potency of the analogue is about sixty times (FSH) and forty times (LH) that of the parent peptide and the increased potency and duration of action of the analogue lead to enhanced biological effect in terms of testosterone release. The prolonged duration of action of the analogue suggests that a single daily dosage regime could be used although further chronic studies with this potent analogue should be undertaken in normal volunteers to determine optimum dosage schedules. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：297 / 303
页数：7
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