THE BIOLOGY OF STEM-CELL FACTOR, A NEW HEMATOPOIETIC GROWTH-FACTOR INVOLVED IN STEM-CELL REGULATION

被引：12
作者：
GALLI, MC
GIARDINA, PJV
MIGLIACCIO, AR
MIGLIACCIO, G
机构：
[1] NEW YORK BLOOD CTR, LINDSLEY F KIMBALL RES INST, NEW YORK, NY 10021 USA
[2] IST SUPER SANITA, I-00161 ROME, ITALY
[3] NEW YORK HOSP, DIV PEDIAT, NEW YORK, NY 10021 USA
来源：
INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH | 1993年 / 23卷 / 02期
关键词：
STEM CELL FACTOR; C-KIT; STEM CELLS; HEMATOPOIESIS; DIAMOND-BLACKFAN ANEMIA;
D O I：
10.1007/BF02592286
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Recently, a new hematopoietic growth factor, stem cell factor, the ligand for the c-kit-proto-oncogene, has been cloned. The gene for this factor or for its receptor are deleted in two well known series of mice mutants which display pleiotropic stem cell defects. Therefore, this factor supposedly plays an important role in stem cell biology. This paper reviews some of the elegant genetic work which led to the discovery of the factor and of its receptor, the biological effects that this factor exerts in the hematopoietic system in normal individuals and in patients with Diamond-Blackfan anemia and speculates on some of its potential clinical applications.
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收藏
页码：70 / 77
页数：8
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