INHIBITORY EFFECT OF OCTOPAMINE ON DOPAMINE-D-1 RECEPTOR IN STRIATAL HOMOGENATES OF THE RAT

被引：7
作者：
CHENG, JT [1 ]
SHEN, CL [1 ]
JOU, TC [1 ]
机构：
[1] NATL YANG MING MED COLL,INST NEUROSCI,TAIPEI,TAIWAN
来源：
NEUROSCIENCE RESEARCH | 1990年 / 9卷 / 03期
关键词：
OCTOPAMINE; DOPAMINE-D-1; RECEPTOR; SCH-23390; CYCLIC AMP; N-0437; RAT STRIATUM;
D O I：
10.1016/0168-0102(90)90005-Y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In the striatal homogenates of rats, octopamine produced a dose-dependent inhibition of dopamine D-1 receptor both in the receptor binding of [3H]Sch-23390 and the formation of cyclic adenosine 3',5'-monophosphate (cyclic AMP) stimulated by dopamine in the presence of sulpiride. Failure of octopamine in the displacement of binding with [3H]N-0437, one of the radioligands for the dopamine D-2 receptor, indicated the specific selectivity of octopamine to dopamine D-1 receptor sites. Lack of effect on forskolin-stimulated formation of cyclic AMP ruled out the possible direct effect of octopamine on adenylate cyclase. These results suggest that octopamine possesses the ability to bind to striatal dopamine D-1 receptor of rats.
引用
收藏
页码：202 / 207
页数：6
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