Regulation of p21(ras) by GTPase activating proteins and guanine nucleotide exchange proteins

被引：59

作者：

Downward, Julian ^{[1
]}

机构：

[1] Lincolns Inn Fields, Imperial Canc Res Fund, London WC2A 3PX, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1992年 / 2卷 / 01期

关键词：

colony stimulating factor; CSF; EGF; epidermal growth factor; GAP; GAP-related domain; GDP dissociation stimulators; GDP releasing factor; GDR; GDS; GEF; GIP; GM; granulocyte macrophage; GRF; GTPase activating protein; GTPase inhibitory protein; guanine nucleotide exchange factor; IL; interleukin; neurofibromatosis type 1; NF1; PDGF; platelet-derived growth factor; Ras exchange protein; REP; SH; Src homology;

D O I：

10.1016/S0959-437X(05)80315-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ras proteins play a critical role in controlling normal cellular growth and, when activated by mutation, in causing malignant transformation. Regulation of p21(ras) is achieved by GTPase activating proteins, which control the rate of hydrolysis of GTP to GDP, and also by GDP dissociation stimulators, which catalyze the exchange of guanine nucleotides. Several such proteins have now been identified and their control mechanisms characterized.

引用

页码：13 / 18

页数：6

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