EFFECTS OF ENDORPHIN DERIVATIVES ON THE EEG ALTERATIONS INDUCED BY CORTICOTROPIN RELEASING-FACTOR IN THE RABBIT HIPPOCAMPUS

被引：11
作者：
PIERETTI, S
ORTOLANI, E
DIGIANNUARIO, A
LOIZZO, A
机构：
[1] Istituto Superiore di Sanità, 00161 Roma
来源：
PHARMACOLOGICAL RESEARCH | 1990年 / 22卷 / 05期
关键词：
CRF; EEG; endorphin; limbic seizures;
D O I：
10.1016/S1043-6618(05)80055-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Corticotropin releasing factor (CRF), injected into the cerebral ventricles (i.c.v.) of rabbits, induced EEG limbic seizures, behavioural excitability, stereotyped behaviour and the tardive enhancement of hippocampal theta voltage and frequency. The β-endorphin cleavage derivatives des-tyr-γ-endorphin (DTγE) and des-enkephalin-γ-endorphin (DEγE), when injected i.v. for 4 days prevented the EEG ictal seizures induced by CRF in the hippocampus of rabbits and partly prevented the tardive enhancement of theta wave amplitude and frequency. These results suggest the possibility that these peptides may have antiepileptogenic properties. © 1990 The Italian Pharmacological Society.
引用
收藏
页码：627 / 633
页数：7
相关论文
共 16 条
[1]   CORTICOTROPIN RELEASING-FACTOR DECREASES POSTBURST HYPERPOLARIZATIONS AND EXCITES HIPPOCAMPAL-NEURONS [J].
ALDENHOFF, JB ;
GRUOL, DL ;
RIVIER, J ;
VALE, W ;
SIGGINS, GR .
SCIENCE, 1983, 221 (4613) :875-877
[2]   BIOCHEMICAL-EVIDENCE FOR A TRANSMITTER ROLE OF DOPAMINE IN THE RAT HIPPOCAMPUS [J].
BISCHOFF, S ;
SCATTON, B ;
KORF, J .
BRAIN RESEARCH, 1979, 165 (01) :161-165
[3]   CONVERSION OF DES-TYROSINE-GAMMA-ENDORPHIN BY BRAIN SYNAPTIC MEMBRANE-ASSOCIATED PEPTIDASES - IDENTIFICATION OF GENERATED PEPTIDE-FRAGMENTS [J].
BURBACH, JPH ;
SCHOTMAN, P ;
VERHOEF, J ;
DEKLOET, ER ;
DEWIED, D .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 97 (03) :995-1004
[4]   NEUROLEPTIC-LIKE ACTIVITY OF PEPTIDES RELATED TO [DES-TYR1]-GAMMA-ENDORPHIN - STRUCTURE ACTIVITY STUDIES [J].
DEWIED, D ;
VANREE, JM ;
GREVEN, HM .
LIFE SCIENCES, 1980, 26 (19) :1575-1579
[5]   NEUROLEPTIC ACTIVITY OF NEUROPEPTIDE BETA-LPH62-77 ([DES-TYR1]GAMMA-ENDORPHIN DT GAMMA-E) [J].
DEWIED, D ;
KOVACS, GL ;
BOHUS, B ;
VANREE, JM ;
GREVEN, HM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 49 (04) :427-436
[6]   CORTICOTROPIN RELEASING-FACTOR PRODUCES INCREASES IN BRAIN EXCITABILITY AND CONVULSIVE SEIZURES IN RATS [J].
EHLERS, CL ;
HENRIKSEN, SJ ;
WANG, M ;
RIVIER, J ;
VALE, W ;
BLOOM, FE .
BRAIN RESEARCH, 1983, 278 (1-2) :332-336
[7]   MODULATION BY DOPAMINE OF POPULATION RESPONSES AND CELL-MEMBRANE PROPERTIES OF HIPPOCAMPAL CA1 NEURONS INVITRO [J].
GRIBKOFF, VK ;
ASHE, JH .
BRAIN RESEARCH, 1984, 292 (02) :327-338
[8]   DIFFERENT EPILEPTOGENIC ACTIVITIES OF MURINE AND OVINE CORTICOTROPIN-RELEASING FACTOR [J].
MARROSU, F ;
MEREU, G ;
FRATTA, W ;
CARCANGIU, P ;
CAMARRI, F ;
GESSA, GL .
BRAIN RESEARCH, 1987, 408 (1-2) :394-398
[9]  
Monnier M., 1961, ATLAS STEREOTAXIC BR
[10]  
ORTOLANI E, 1987, ADV BIOCHEM PSYCHOPH, V43, P329
12