MUTAGENIC EFFECTS OF OZONE ON HUMAN-CELLS EXPOSED INVIVO AND INVITRO BASED ON SISTER CHROMATID EXCHANGE ANALYSIS

被引：43

作者：

GUERRERO, RR

ROUNDS, DE

OLSON, RS

HACKNEY, JD

机构：

[1] Pasadena Foundation for Medical Research, Pasadena

来源：

ENVIRONMENTAL RESEARCH | 1979年 / 18卷 / 02期

关键词：

D O I：

10.1016/0013-9351(79)90110-5

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A sister chromatid exchange (SCE) analysis was performed on circulating lymphocytes collected from young human volunteers exposed to 0.5 ppm ozone for 2 h, an exposure simulating conditions in severe air pollution episodes. SCE analysis was also performed on diploid human fetal lung cells (WI-38) exposed to 0, 0.25, 0.50, 0.75 and 1.00 ppm ozone for 1 h in vitro. No increase in SCE over controls was demonstrated in the lymphocyte chromosomes. A clear dose-related increase in SCE was observed in the WI-38 cells exposed in vitro.

引用

页码：336 / 346

页数：11

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