COLLAGEN HETEROGENEITY IN HUMAN CARTILAGE - IDENTIFICATION OF SEVERAL NEW COLLAGEN CHAINS

被引：303

作者：

BURGESON, RE ^{[1
]}

HOLLISTER, DW ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,HARBOR GEN HOSP,LOS ANGELES CTY HARBOR MED CTR,DEPT MED,TORRANCE,CA 90509

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0006-291X(79)80024-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Normal human hyaline cartilages contain five distinguishable coltagenous proteins in addition to, and different from the αl(II) chain of Type II collagen. This report describes the characterization of three of these additional proteins. By the criteria of solubility, electrophoretic mobilities, ion-exchange and sieve chromatographic properties, amino acid compositions, and cyanogen bromide peptide profiles, at least two of these proteins, and possibly the third, are structurally distinct collagen α chains different from previously reported collagen chains. These findings imply further molecular heterogeneity of vertebrate collagens, and the existence of at least 9 different structural genes for collagen chains. © 1979 Academic Press, Inc. All rights of reproduction in any form reserved.

引用

页码：1124 / 1131

页数：8

共 16 条

[1] FETAL MEMBRANE COLLAGENS - IDENTIFICATION OF 2 NEW COLLAGEN ALPHA-CHAINS [J].