Unplanned pregnancy on a direct oral anticoagulant (Rivaroxaban): A warning

被引：18

作者：

Myers, B. ^{[1
,2
]}

Neal, R. ^{[3
]}

Myers, O. ^{[1
]}

Ruparelia, M. ^{[1
]}

机构：

[1] Leicester Royal Infirm, Dept Haematol, Infirm Sq, Leicester LE1 5WW, Leics, England

[2] Lincoln Cty Hosp, Lincoln, England

[3] UEA Med Sch, Norwich, Norfolk, England

来源：

OBSTETRIC MEDICINE | 2016年 / 9卷 / 01期

关键词：

Anticoagulants; pregnancy; direct oral anticoagulants; heavy menstrual bleeding; Rivaroxaban;

D O I：

10.1177/1753495X15621814

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Direct oral anticoagulants (DOACs or NOACs -non-vitamin K oral anticoagulants), as the name suggests, are oral anticoagulants with a direct inhibitory action either against factor X or factor II (thrombin). Pregnant women were excluded from participating in all the large trials of the DOACs and they are considered contra-indicated in pregnancy and breast feeding. We present a case of inadvertent exposure to rivaroxaban in a woman who presented at 25 weeks' gestation. The management of her pregnancy and delivery is described, and the previous published case reports are reviewed with a discussion about the use of DOACs in woman of childbearing age.

引用

页码：40 / 42

页数：3

共 8 条

[1] VTE, Thrombophilia, Antithrombotic Therapy, and Pregnancy Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [J].

Bates, Shannon M. ;

Greer, Ian A. ;

Middeldorp, Saskia ;

Veenstra, David L. ;

Prabulos, Anne-Marie ;

Vandvik, Per Olav .

CHEST, 2012, 141 (02) :E691S-E736S

[2] Use of contraceptive methods by women with current venous thrombosis on anticoagulant therapy: a systematic review [J].

Culwell, Kelly R. ;

Curtis, Kathryn M. .

CONTRACEPTION, 2009, 80 (04) :337-345

[3] Abnormal uterine bleeding in VTE patients treated with rivaroxaban compared to vitamin K antagonists [J].

De Crem, Nico ;

Peerlinck, Kathelijne ;

Vanassche, Thomas ;

Vanheule, Kristine ;

Debaveye, Barbara ;

Middeldorp, Saskia ;

Verhamme, Peter ;

Peetermans, Marijke .

THROMBOSIS RESEARCH, 2015, 136 (04) :749-753

[4]

EMC, SUMMARY PRODUCT CHAR

[5]

European Medicines Agency. CHMP assessment report for Xarelto, EMEA5435192008

[6]

Ferreira M, 2015, BRIT J HAEMATOL, V162, P717

[7] Menstrual problems and contraception in women of reproductive age receiving oral anticoagulation [J].

Huq, Farah Yasmine ;

Tvarkova, Katerina ;

Arafa, Aliaa ;

Kadir, Rezan A. .

CONTRACEPTION, 2011, 84 (02) :128-132

[8] Oral anticoagulation with rivaroxaban during pregnancy: a case report [J].

Koenigsbruegge, Oliver ;

Langer, Martin ;

Hayde, Michael ;

Ay, Cihan ;

Pabinger, Ingrid .

THROMBOSIS AND HAEMOSTASIS, 2014, 112 (06) :1323-1324

← 1 →