BINDING TO DNA AND THE RETINOBLASTOMA GENE-PRODUCT PROMOTED BY COMPLEX-FORMATION OF DIFFERENT E2F FAMILY MEMBERS

被引：242
作者：
KREK, W
LIVINGSTON, DM
SHIRODKAR, S
机构：
[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115
[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115
来源：
SCIENCE | 1993年 / 262卷 / 5139期
关键词：
D O I：
10.1126/science.8248803
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The E2F family of transcription factors functions in the control of the mammalian cell cycle. Here it is shown that two family members, E2F-1 and DP-1, form specific heterodimers in vivo, a process that enhances DNA binding, transactivation, and the binding of the retinoblastoma gene product. These results suggest that heterodimerization regulates E2F function and contributes to cell cycle control.
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页码：1557 / 1560
页数：4
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