THE HUMAN TYR03 GENE AND PSEUDOGENE ARE LOCATED IN CHROMOSOME 15Q14-Q25

被引：24

作者：

POLVI, A

ARMSTRONG, E

LAI, C

LEMKE, G

HUEBNER, K

SPRITZ, RA

GUIDA, LC

NICHOLLS, RD

ALITALO, K

机构：

[1] UNIV HELSINKI,DEPT PATHOL,MOLEC CANC BIOL LAB,SF-00014 HELSINKI,FINLAND

[2] SALK INST,MOLEC NEUROBIOL LAB,SAN DIEGO,CA 92138

[3] THOMAS JEFFERSON UNIV,JEFFERSON CANC INST,DEPT MICROBIOL,PHILADELPHIA,PA 19107

[4] UNIV WISCONSIN,DEPT MED GENET,MADISON,WI 53706

[5] UNIV WISCONSIN,DEPT PEDIAT,MADISON,WI 53706

[6] CASE WESTERN RESERVE UNIV,DEPT GENET,CLEVELAND,OH 44106

来源：

GENE | 1993年 / 134卷 / 02期

关键词：

TYROSINE KINASE; RECEPTOR; PROCESSED PSEUDOGENE;

D O I：

10.1016/0378-1119(93)90109-G

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Partial cDNAs of the human TYRO3 gene, encoding a putative receptor tyrosine kinase, and its processed pseudogene (TYRO3P) were cloned from human teratocarcinoma cell, bone marrow and melanocyte cDNA libraries. The tyrosine kinase homologous domains of TYRO3 and TYRO3P were sequenced and compared with each other and with the mouse TYRO3 gene. Abundant levels of the 4.2-kb TYRO3 mRNA were detected in human brain, and lower levels in other human tissues. TYRO3 and TYRO3P were both assigned to human chromosome 15q14-q25 by analysis of DNAs from somatic cell hybrids.

引用

页码：289 / 293

页数：5

共 24 条

[1] THE C-SRC TYROSINE KINASE (CSK) GENE, A POTENTIAL ANTIONCOGENE, LOCALIZES TO HUMAN-CHROMOSOME REGION 15Q23-]Q25 [J].