Development of a multivariable prediction model for anal high-grade squamous intraepithelial lesions in persons living with HIV in Puerto Rico: A cross-sectional study

被引：0

作者：

Soto-Salgado, Marievelisse ^{[1
,2
,11
]}

Suarez, Erick ^{[3
]}

Viera-Rojas, Tariz D. ^{[4
]}

Pericchi, Luis R. ^{[5
]}

Ramos-Cartagena, Jeslie M. ^{[6
]}

Deshmukh, Ashish A. ^{[7
,8
]}

Tirado-Gomez, Maribel ^{[9
,10
]}

Ortiz, Ana Patricia ^{[1
,3
]}

机构：

[1] Univ Puerto Rico UPR, Div Canc Control & Populat Sci, Comprehens Canc Ctr, San Juan, PR 00925 USA

[2] Grad Sch Publ Hlth, Dept Hlth Serv Adm, UPR Med Sci Campus, San Juan, PR 15261 USA

[3] Grad Sch Publ Hlth, Dept Biostat & Epidemiol, UPR Med Sci Campus, San Juan, PR USA

[4] UPR Comprehens Canc Ctr, Canc Prevent & Control Res CAPAC Training Program, Div Canc Control & Populat Sci, San Juan, PR USA

[5] Fac Nat Sci, Dept Math, UPR Rio Piedras Campus, San Juan, PR USA

[6] UPR, MDACC Partnership Excellence Canc Res Program, UPR Med Sci Campus, San Juan, PR USA

[7] Med Univ South Carolina, Dept Publ Hlth Sci, Charleston, SC USA

[8] Med Univ South Carolina, Hollings Canc Ctr, Charleston, SC USA

[9] UPR Comprehens Canc Ctr, Div Canc Med, San Juan, PR USA

[10] Sch Med, Dept Med, Hematol Oncol Program, UPR Med Sci Campus, San Juan, PR USA

[11] Univ Puerto Rico, Comprehens Canc Ctr, PMB 371,POB 70344, San Juan, PR 00936 USA

来源：

LANCET REGIONAL HEALTH-AMERICAS | 2023年 / 17卷

关键词：

Hispanics; Persons living with HIV; Anal HSIL; Early detection; Prediction model;

D O I：

暂无

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background Persons living with HIV (PLWH) are at high risk of developing anal high-grade squamous intraepithelial lesions (HSIL). We aimed to develop a prediction model for anal HSIL based on individual characteristics of PLWH.Methods Cross-sectional study of PLWH aged >= 21 years who attended the Anal Neoplasia Clinic of the University of Puerto Rico Comprehensive Cancer Center from 2016 to 2022. The primary outcome was biopsy-confirmed anal HSIL. For each sex, relations between potential predictors and HSIL were examined using univariate (ULRM) and multivariable (MLRM) logistic regression models. Risk modelling was performed with MLRM and validated with bootstrapping techniques. The area under the ROC Curves (AUC) was estimated with 95% CI.Findings HSIL was detected among 45.11% of patients, 68.48% were males, and 59.42% were >= 45 aged. Multivariable analysis showed that, in women, the only significant predictor for HSIL was having a previous abnormal anal cytology (p = 0.01). In men, significant predictors for HSIL were having a previous abnormal anal cytology (p < 0.001) and a history of infection with any gonorrhoea (p = 0.002). Other suggestive predictors for HSIL among women were obesity and smoking. No association between smoking and HSIL among men was observed (p < 0.05). The AUC estimated among women (0.732, 95% CI: 0.651-0.811) was higher than in men (0.689, 95% CI: 0.629-0.748). Interpretation Our results support that the inclusion of individual characteristics into the prediction model will adequately predict the presence of HSIL in PLWH.Funding This work was supported by the NCI (Grants #U54CA096297, #R25CA240120), the NIGMS (Grant #U54GM133807), and the NIMHD (Grant #U54MD007587).Copyright Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).Keywords: Hispanics; Persons living with HIV; Anal HSIL; Early detection; Prediction model Health 2023;17: Published https://doi.org/10. 1016/j.lana.2022. 100382

引用

页数：14

共 41 条

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