FETAL HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION OF DIFFERENT ORGANS IN THE 2ND TRIMESTER

被引:76
作者
MANO, H
CHERMANN, JC
机构
[1] CAMPUS UNIV LUMINY,UNITE RECH RETROVIRUS & MALAD ASSOCIEES,INSERM,U322,BP 33,F-13273 MARSEILLE 9,FRANCE
[2] NAGOYA UNIV,SCH MED,DEPT OBSTET & GYNECOL,SHOWA KU,NAGOYA,AICHI 466,JAPAN
关键词
D O I
10.1089/aid.1991.7.83
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human immunodeficiency virus type 1 (HIV-1) infection in utero was examined by isolating the virus and detecting the HIV-1 DNA sequence from different fetal tissues. The brain, thymus, lung, liver, spleen, and placenta tissues from fetuses (10-23 weeks of gestation) born to HIV-1-infected asymptomatic mothers were examined. HIV-1 was isolated from 2 of 7, 1 of 7, and 1 of 7 cocultures of splenic, thymic, and trypsin-resistant cells from the liver and placenta, respectively, with peripheral blood mononuclear cells; 20-30% and 40-60% of splenic and of thymic cells were CD4+ lymphoid cells and 40-80% of trypsin-resistant cells were mononuclear phagocytes. The HIV-1 DNA sequence was detected in 4 of 7, 3 of 7, 1 of 7, 2 of 7, and 2 of 6 samples from the spleen, thymus, brain, lung, liver, and placenta, respectively, using the polymerase chain reaction. In one case, the intensity of the HIV-1 DNA sequence appeared to be correlated with the success of viral isolation. We indicate that fetal HIV-1 infection may frequently occur in the second trimester and the cells responsible for the infection may be CD4+ lymphoid cells and mononuclear phagocytes.
引用
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页码:83 / 88
页数:6
相关论文
共 30 条
[11]   DETECTION OF LYMPHOCYTES EXPRESSING HUMAN LYMPHOTROPIC-T VIRUS TYPE-III IN LYMPH-NODES AND PERIPHERAL-BLOOD FROM INFECTED INDIVIDUALS BY INSITU HYBRIDIZATION [J].
HARPER, ME ;
MARSELLE, LM ;
GALLO, RC ;
WONGSTAAL, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (03) :772-776
[12]  
JOVAISAS E, 1985, LANCET, V2, P1129
[13]   HUMAN IMMUNODEFICIENCY VIRUS-INFECTION OF NEWBORNS [J].
KATZ, SL ;
WILFERT, CM .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (25) :1687-1689
[14]   CYTOKINES ALTER PRODUCTION OF HIV-1 FROM PRIMARY MONONUCLEAR PHAGOCYTES [J].
KOYANAGI, Y ;
OBRIEN, WA ;
ZHAO, JQ ;
GOLDE, DW ;
GASSON, JC ;
CHEN, ISY .
SCIENCE, 1988, 241 (4873) :1673-1675
[15]  
LAURE F, 1988, LANCET, V2, P538
[16]   HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-III (HTLV-III) EMBRYOPATHY - A NEW DYSMORPHIC SYNDROME ASSOCIATED WITH INTRAUTERINE HTLV-III INFECTION [J].
MARION, RW ;
WIZNIA, AA ;
HUTCHEON, RG ;
RUBINSTEIN, A .
AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1986, 140 (07) :638-640
[17]  
MUNDY DC, 1987, LANCET, V2, P459
[18]   REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS IN MONOCYTES - GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) POTENTIATES VIRAL PRODUCTION YET ENHANCES THE ANTIVIRAL EFFECT MEDIATED BY 3'-AZIDO-2'3'-DIDEOXYTHYMIDINE (AZT) AND OTHER DIDEOXYNUCLEOSIDE CONGENERS OF THYMIDINE( [J].
PERNO, CF ;
YARCHOAN, R ;
COONEY, DA ;
HARTMAN, NR ;
WEBB, DSA ;
HAO, Z ;
MITSUYA, H ;
JOHNS, DG ;
BRODER, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (03) :933-951
[19]   CHARACTERIZATION OF THE RNA DEPENDENT DNA-POLYMERASE OF A NEW HUMAN T-LYMPHOTROPIC RETROVIRUS (LYMPHADENOPATHY ASSOCIATED VIRUS) [J].
REY, MA ;
SPIRE, B ;
DORMONT, D ;
BARRESINOUSSI, F ;
MONTAGNIER, L ;
CHERMANN, JC .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 121 (01) :126-133
[20]   USE OF THE POLYMERASE CHAIN-REACTION FOR EARLY DETECTION OF THE PROVIRAL SEQUENCES OF HUMAN IMMUNODEFICIENCY VIRUS IN INFANTS BORN TO SEROPOSITIVE MOTHERS [J].
ROGERS, MF ;
OU, CY ;
RAYFIELD, M ;
THOMAS, PA ;
SCHOENBAUM, EE ;
ABRAMS, E ;
KRASINSKI, K ;
SELWYN, PA ;
MOORE, J ;
KAUL, A ;
GRIMM, KT ;
BAMJI, M ;
SCHOCHETMAN, G .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (25) :1649-1654