Efficacy of HCV treatment in Poland at the turn of the interferon era - the EpiTer study

被引：20

作者：

Flisiak, Robert ^{[1
]}

Pogorzelska, Joanna ^{[1
]}

Berak, Hanna ^{[2
]}

Horban, Andrzej ^{[2
]}

Orlowska, Iwona ^{[3
]}

Simon, Krzysztof ^{[3
]}

Tuchendler, Ewelina ^{[4
]}

Madej, Grzegorz ^{[4
]}

Piekarska, Anna ^{[5
]}

Jablkowski, Maciej ^{[6
]}

Deron, Zbigniew ^{[7
]}

Mazur, Wlodzimierz ^{[8
]}

Kaczmarczyk, Marcin ^{[8
]}

Janczewska, Ewa ^{[9
]}

Pisula, Arkadiusz ^{[9
]}

Smykal, Jacek ^{[10
]}

Nowak, Krzysztof ^{[10
]}

Matukiewicz, Marek ^{[10
]}

Halota, Waldemar ^{[11
]}

Wernik, Joanna ^{[11
]}

Sikorska, Katarzyna ^{[12
]}

Mozer-Lisewska, Iwona ^{[13
]}

Rozplochowski, Blazej ^{[13
]}

Garlicki, Aleksander ^{[14
]}

Tomasiewicz, Krzysztof ^{[15
]}

Krzowska-Firych, Joanna ^{[15
]}

Baka-Cwierz, Barbara ^{[16
]}

Kryczka, Wieslaw ^{[17
,18
]}

Zarebska-Michaluk, Dorota ^{[17
,18
]}

Olszok, Iwona ^{[19
]}

Boron-Kaczmarska, Anna ^{[20
]}

Sobala-Szczygiel, Barbara ^{[20
]}

Szlauer, Bronislawa ^{[21
]}

Korcz-Ondrzejek, Bogumila ^{[21
]}

Sieklucki, Jerzy ^{[22
]}

Plesniak, Robert ^{[22
]}

Ruszala, Agata ^{[22
]}

Postawa-Klosinska, Barbara ^{[23
]}

Citko, Jolanta ^{[24
]}

Lachowicz-Wawrzyniak, Anna ^{[25
]}

Musialik, Joanna ^{[26
,27
]}

Jezierska, Edyta ^{[28
]}

Dobracki, Witold ^{[29
]}

Dobracka, Beata ^{[29
]}

Halubiec, Jan ^{[30
]}

Krygier, Rafal ^{[31
]}

Strokowska, Anna ^{[32
]}

Chomczyk, Wojciech ^{[32
]}

Witczak-Malinowska, Krystyna ^{[33
]}

机构：

[1] Med Univ Bialystok, Dept Infect Dis & Hepatol, 14 Zurawia St, PL-15540 Bialystok, Poland

[2] Hosp Infect Dis Warsaw, Daily Unit, Warsaw, Poland

[3] Wroclaw Med Univ, Div Infect Dis & Hepatol, Wroclaw, Poland

[4] Voivodship Specialist Hosp, Dept Infect Dis 2, Wroclaw, Poland

[5] Med Univ Lodz, Dept Infect Dis & Hepatol, Lodz, Poland

[6] Med Univ Lodz, Dept Infect Dis & Liver Dis, Lodz, Poland

[7] WSSz Bieganski, Infect Dis Unit, Lodz, Poland

[8] Med Univ Silesia, Clin Dept Infect Dis, Katowice, Poland

[9] ID Clin, Myslowice, Poland

[10] NZOZ LSPChW Sp Zoo, Zielona Gora, Poland

[11] Nicolaus Copernicus Univ, Coll Med, Dept Infect Dis & Hepatol, Bydgoszcz, Poland

[12] Med Univ Gdansk, Dept Trop Med & Epidemiol, Dept Infect Dis, Gdansk, Poland

[13] Poznan Univ Med Sci, Dept Infect Dis, Poznan, Poland

[14] Jagiellonian Univ, Coll Med, Dept Infect & Trop Dis, Krakow, Poland

[15] Med Univ Lublin, Dept Infect Dis & Hepatol, Lublin, Poland

[16] John Paul II Hosp Krakow, Reg Ctr Diag & Treatment Viral Hepatitis & Hepato, Krakow, Poland

[17] Voivodship Hosp, Dept Infect Dis, Kielce, Poland

[18] Jan Kochanowski Univ Humanities & Sci, Kielce, Poland

[19] Raciborz Dist Hosp, Infect Dis Ward, Szczecin, Poland

[20] Med Univ Silesia, Dept Infect Dis, Katowice, Poland

[21] Grp Hlth Care Facil Cieszyn, Cieszyn, Poland

[22] Med Ctr Lancut, Clin Dept Infect Dis, Lancut, Poland

[23] Stefan Zeromski Specialist Municipal Hosp Krakow, Infect Dis Ward, Krakow, Poland

[24] Reg Hosp, Med Practice Infect Dis, Olsztyn, Poland

[25] Gizycko Hosp LLC, Gizycko, Poland

[26] Med Univ Silesia, Sch Med Katowice, Katowice, Poland

[27] Dept Nephrol Transplantol & Internal Dis, Dept Gastroenterol & Hepatol, Katowice, Poland

[28] Voivodship Specialist Hosp, Dept Infect Dis, Czestochowa, Poland

[29] MED FIX Cent Medyczne Wroclaw, Wroclaw, Poland

[30] Dept Infect Dis Boleslawiec, Boleslawiec, Poland

[31] Infect Dis & Hepatol Outpatient Clin NZOZ Gemini, Zychlin, Poland

[32] 107 Mil Hosp Walcz, Ward Infect Dis, Walcz, Poland

[33] Univ Ctr Maritime Med & Trop Dis Gdynia, Gdynia, Poland

来源：

CLINICAL AND EXPERIMENTAL HEPATOLOGY | 2016年 / 2卷 / 04期

关键词：

liver; hepatitis C; therapy;

D O I：

10.5114/ceh.2016.63870

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The aim of the study was to analyze the efficacy achieved with regimens available for chronic hepatitis C (CHC) in Poland between 2013 and 2016. Material and methods: Data were collected from 29 centers and included 6786 patients with available sustained virologic response (SVR) data between 1 January 2013 and 31 March 2016. Results: The sustained virologic response rate for genotypes (G) 1a, 1b, 2, 3 and 4 was 62%, 56%, 92%, 67% and 56% respectively; 71% patients (n = 4832) were treated with pegylated interferon alpha (Peg-IFN alpha) and ribavirin (RBV), with SVR rates of 58%, 49%, 92%, 67% and 55% respectively. The sustained virologic response among 5646 G1 infected patients was the lowest with natural interferon alpha psi (7%, n = 70) or PegIFN (50%, n = 3779) with RBV, and improved in those receiving triple regimens of Peg-IFN + RBV combined with boceprevir (47%, n = 485), telaprevir (64%, n = 805), simeprevir (73%, n = 132) or sofosbuvir (70%, n = 23). The sustained virologic response with interferon-free regimens of sofosbuvir and RBV (n = 7), sofosbuvir and simeprevir (n = 53), and ledipasvir and sofosbuvir (n = 64) achieved 86%, 89% and 94% respectively. The highest SVR of 98% was observed with ombitasvir/paritaprevir combined with dasabuvir (n = 227). Patients infected with G3 (n = 896) and G4 (n = 220) received mostly Peg-IFN + RBV with SVR of 67% and 56% respectively. Interferon-free regimens were administered in 18 G3/G4 patients and all achieved an SVR. Sofosbuvir combined with Peg-IFN and RBV was administered to 33 patients with an SVR rate of 94%, and a similar rate was achieved among 13 G2 patients treated with interferon and RBV. Conclusions: We observed significant differences in efficacy of HCV regimens available in Poland at the turn of the interferon era. The data will be useful as a comparison for therapeutic options expected in the next few years.

引用

页码：138 / 143

页数：6

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