THE LIM DOMAIN - A NEW STRUCTURAL MOTIF FOUND IN ZINC-FINGER-LIKE PROTEINS

被引：348
作者：
SANCHEZGARCIA, I
RABBITTS, TH
机构：
[1] Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, Hills road
来源：
TRENDS IN GENETICS | 1994年 / 10卷 / 09期
关键词：
D O I：
10.1016/0168-9525(94)90034-5
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
An important new family of proteins has recently been described that carries a novel cysteine-rich zinc-binding domain called the LIM domain. This protein family is present in mammals, amphibians, flies, worms and plants and its main function is in developmental regulation. Although a role in protein-protein interaction seems likely, intriguing similarities to GATA zinc fingers imply that the LIM domain may also be involved in binding to specific nucleic acids.
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页码：315 / 320
页数：6
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