Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases

被引：11

作者：

Bragina, Elena Yu ^{[1
]}

Goncharova, Irina A. ^{[1
]}

Garaeva, Anna F. ^{[1
,2
]}

Nemerov, Evgeniy, V ^{[2
]}

Babovskaya, Anastasija A. ^{[2
]}

Karpov, Andrey B. ^{[3
]}

Semenova, Yulia, V ^{[4
]}

Zhalsanova, Irina Z. ^{[1
]}

Gomboeva, Densema E. ^{[1
]}

Saik, Olga, V ^{[5
]}

Zolotareva, Olga, I ^{[6
,7
,8
]}

Ivanisenko, Vladimir A. ^{[5
]}

Dosenko, Victor E. ^{[9
]}

Hofestaedt, Ralf ^{[6
]}

Freidin, Maxim B. ^{[1
]}

机构：

[1] Tomsk NRMC, Res Inst Med Genet, Tomsk, Russia

[2] Siberian State Med Univ, Tomsk, Russia

[3] Fed Med Biol Agcy, Seversk Biophys Res Ctr, Seversk, Russia

[4] Seversk Clin Hosp, Fed Med Biol Agcy, Siberian Fed Res & Clin Ctr, Seversk, Russia

[5] Russian Acad Sci, Siberian Branch, Fed Res Ctr Inst Cytol & Genet, Novosibirsk, Russia

[6] Bielefeld Univ, Bioinformat Med Informat Dept, Bielefeld, Germany

[7] Bielefeld Univ, Fac Technol, Int Res Training Grp Computat Methods Anal Divers, Bielefeld, Germany

[8] Bielefeld Univ, Ctr Biotechnol, Bielefeld, Germany

[9] Natl Acad Sci, Bogomoletz Inst Physiol, Kiev, Ukraine

来源：

JOURNAL OF INTEGRATIVE BIOINFORMATICS | 2018年 / 15卷 / 04期

关键词：

Comorbidity; Bronchial Asthma; Hypertension; eQTL; SNP;

D O I：

10.1515/jib-2018-0052

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Comorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation. The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension, on one hand, and single nucleotide polymorphisms associated with regulation of gene expression (eQTL), on the other hand. A total of 96 eQTL SNPs were genotyped in 587 Russian individuals. Bronchial asthma alone was found to be associated with rs1927914 (TLR4), rs1928298 (intergenic variant), and rs1980616 (SERPINA1); hypertension alone was found to be associated with rs11065987 (intergenic variant); rs2284033 (IL2RB), rs11191582 (NT5C2), and rs11669386 (CARDS); comorbidity between asthma and hypertension was found to be associated with o rs1010461 (ANG/RNASE4), rs7038716, rs7026297 (LOC105376244), rs7025144 (intergenic variant), and rs2022318 (intergenic variant). The results suggest that genetic background of comorbidity of asthma and hypertension is En different from genetic backgrounds of both diseases manifesting isolated.

引用

页数：7

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