ENANTIOSELECTIVE CONJUGATE ADDITION GREATLY IMPROVES THE SYNTHESIS OF (+)-CONFERTIN

被引：25

作者：

QUINKERT, G

MULLER, T

KONIGER, A

SCHULTHEIS, O

SICKENBERGER, B

DURNER, G

机构：

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 24期

关键词：

ENANTIOSELECTIVE CONJUGATE ADDITION; CHIRAL LIGAND-MODIFIED ORGANOCUPRATES; TOTAL SYNTHESIS OF (+)-CONFERTIN;

D O I：

10.1016/S0040-4039(00)92665-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The five-membered ring building blocks 2+3 are enantioselectively produced by conjugate addition of a chiral ligand-modified organocuprate to 2-methylcyclopent-2-enone (1) (chemical yield: 88%; e.e.: 88%) and successfully converted in a multi-step sequence, after final enantioselection by recrystallization of an appropriate intermediate, into the pseudoguaianolide (+)-confertin (5).

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页码：3469 / 3472

页数：4

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