THE 1ST TOTAL SYNTHESIS OF THE ANTITHROMBIN-III BINDING-SITE OF PORCINE MUCOSA HEPARIN

被引：21
作者：
DUCHAUSSOY, P
LEI, PS
PETITOU, M
SINAY, P
LORMEAU, JC
CHOAY, J
机构：
[1] SANOFI RECH,CTR CHOAY,9 RUE PRESIDENT SALVADOR ALLENDE,F-94256 GENTILLY,FRANCE
[2] ECOLE NORM SUPER,CNRS,CHIM LAB,F-75231 PARIS 05,FRANCE
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 02期
关键词：
D O I：
10.1016/S0960-894X(00)80239-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of a pentasaccharide containing a N-acetyl-glucosamine unit and corresponding to the major natural sequence required in heparin for binding to antithrombin III is reported for the first time. This compound elicits anti-factor Xa activity and high affinity for antithrombin III.
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页码：99 / 102
页数：4
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