CONTROLLED RELEASE INDOMETHACIN MICROSPHERES PREPARED BY USING AN EMULSION SOLVENT-DIFFUSION TECHNIQUE

被引：26
作者：
MALAMATARIS, S
AVGERINOS, A
机构：
[1] Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Thessaloniki, Thessaloniki
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 62卷 / 2-3期
关键词：
Acrylic polymer; Controlled release; Emulsion solvent-diffusion technique; Indomethacin microsphere;
D O I：
10.1016/0378-5173(90)90223-Q
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The feasibility of producing controlled release indomethacin microspheres, with acrylic polymers Eudragit RS and RL, by employing two emulsion solvent-diffusion systems, is compared. Microspheres with various polymer/drug ratios and polymer combinations (Eudragit RS/RL ratios) were prepared. The physical properties, loading efficiency and dissolution behaviour depended on the emulsion solvent-diffusion technique, polymer/drug ratio and polymer combination. The drug release is described on the basis of two bi-exponential, first-order models. © 1990.
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页码：105 / 111
页数：7
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