IMPROVED ELECTRON-CAPTURE GLC-DETERMINATION OF ALPRENOLOL AND OXPRENOLOL IN SERUM USING A WALL-COATED OPEN TUBULAR COLUMN

An accurate, rapid, and sensitive GLC determination of alprenolol and oxprenolol in serum is described. This method combines an electron‐capture detector with a wall‐coated open tubular column. The lowest detectable amount of the halogenated (heptafluoroacyl) derivatives of alprenolol and oxprenolol is 2 pg. The high resolving power and the rapid elution time of the wall‐coated open tubular column dramatically improve the performance (accuracy and sensitivity) of the conventional electron‐capture detector and packed column system in these determinations. This method allows the use of small volumes of sample (100–200 μl), does not require redistilled reagents, and has a simplified extraction procedure. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company