GLYCOPROTEIN GB OF HERPES-SIMPLEX VIRUS EXPRESSES TYPE-COMMON AND TYPE-SPECIFIC ANTIGENIC DETERMINANTS INVIVO

被引：3
作者：
DIX, RD
机构：
[1] UNIV MIAMI,SCH MED,BASCOM PALMER EYE INST,DEPT NEUROL,MIAMI,FL 33101
[2] UNIV MIAMI,SCH MED,BASCOM PALMER EYE INST,DEPT MICROBIOL & IMMUNOL,MIAMI,FL 33101
来源：
JOURNAL OF MEDICAL VIROLOGY | 1990年 / 30卷 / 03期
关键词：
monoclonal antibodies; neurological diseases; passive transfer;
D O I：
10.1002/jmv.1890300309
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Four monoclonal antibodies directed against glycoprotein B of herpes simplex virus were evaluated for their ability to immunize mice passively against acute virus‐induced neurological illness and death when administered intraperitoneally 2 hours prior to footpad challenge with type 1 or type 2 virus. Two monoclonal antibodies, H120 and H157, failed to reduce the severity of neurological disease in infected animals. In contrast, H233 and H368 antibodies provided significant protection in type‐common and type‐specific fashions, respectively. A direct correlation was observed between in vitro neutralization and in vivo protection. These results provide the first in vivo evidence that glycoprotein gB of herpes simplex virus expresses both type‐common and type‐specific determinants during the evolution of acute virus‐induced neurological disease. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码：192 / 195
页数：4
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