COMBINATION OF NICOTINOMIDE OND STEROID VERSUS NICOTINAMIDE IN RECENT-ONSET IDDM - THE IMDIAB-II STUDY

被引：14

作者：

POZZILLI, P ^{[1
]}

VISALLI, N ^{[1
]}

BOCCUNI, ML ^{[1
]}

BARONI, MG ^{[1
]}

BUZZETTI, R ^{[1
]}

FIORITI, E ^{[1
]}

SIGNORE, A ^{[1
]}

CAVALLO, MG ^{[1
]}

ANDREANI, D ^{[1
]}

LUCENTINI, L ^{[1
]}

MATTEOLI, MC ^{[1
]}

CRINO, A ^{[1
]}

CICCONETTI, CA ^{[1
]}

TEODONIO, C ^{[1
]}

AMORETTI, R ^{[1
]}

PISANO, L ^{[1
]}

PENNAFINA, MG ^{[1
]}

SANTOPADRE, G ^{[1
]}

MAROZZI, G ^{[1
]}

MULTARI, G ^{[1
]}

CAMPEA, L ^{[1
]}

SUPPA, MA ^{[1
]}

DEMATTIA, GC ^{[1
]}

FALDETTA, MC ^{[1
]}

MARIETTI, G ^{[1
]}

PERRONE, F ^{[1
]}

GRECO, AV ^{[1
]}

GHIRLANDA, G ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,IST CLIN MED 2,ROME,ITALY

来源：

DIABETES CARE | 1994年 / 17卷 / 08期

关键词：

D O I：

10.2337/diacare.17.8.897

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - The aim of this study was to compare the effect of nicotinamide (NCT) alone or in combination with a cortisone-like substance, deflazacort (DFL), on the integrated parameters of metabolic control in patients with the recent-onset of insulin-dependent diabetes mellitus (IDDM). RESEARCH DESIGN AND METHODS - Thirty-six patients who were diagnosed with diabetes between 5 and 35 years of age entered a randomized, double-blind, 1-year prospective study. Group A (n = 18) received NCT for 1 year (25 mg.kg(-1).day(-1) plus DFL for 3 months (0.6 mg.kg(-1).day(-1) in the first month, 0.3 mg.kg(-1).day(-1) in the other 2 months). Group B (n = 18) received NCT for 1 year (25 mg.kg(-1).day(-1)) plus placebo for the first 3 months. All patients were treated with intensified insulin therapy. RESULTS - At 3 months after diagnosis, the insulin dose was significantly higher in group A compared with group B (P < 0.03) with similar HbA(1) levels. Basal and stimulated C-peptide levels in group A of both adults and children were significantly higher compared with patients of group B (P < 0.05 and P < 0.03, respectively). At the end of a 1-year follow-up, basal C-peptide did not differ between the two groups, although stimulated C-peptide was still significantly higher in patients of group A compared with group B (P < 0.05). Finally, insulin requirement did not differ between the two groups.

引用

页码：897 / 900

页数：4

共 22 条

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