SUB-CHROMOSOMAL DNA-SYNTHESIS IN X-IRRADIATED V-79 CELLS

被引：27

作者：

DAHLE, D

GRIFFITHS, TD

CARPENTER, JG

机构：

来源：

RADIATION RESEARCH | 1979年 / 78卷 / 03期

关键词：

D O I：

10.2307/3574979

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of X radiation on DNA replication in Chinese hamster V-79 cells has been investigated by DNA fiber autoradiography. The only effect observed at the replicon level is a reduction in the frequency of initiation events. The dose-response for this reduction is multiphasic indicating that some initiation events are much more radioresistant than others. When the data obtained from DNA fiber autoradiography are compared to kinetic data for thymidine incorporation, it is evident that at least for V-79 cells, the effects of X radiation on thymidine uptake into acid-precipitable material can be entirely accounted for by alterations in the frequency of initiation of replicon clusters.

引用

页码：542 / 549

页数：8

共 13 条

[1]

DAHLE DB, 1978, MOL PHARMACOL, V14, P278

[2] SOME EFFECTS OF X-IRRADIATION ON THE METABOLISM OF DEOXYRIBONUCLEIC ACID IN MAMMALIAN CELLS GROWN IN CULTURE [J].

DICKSON, MSH ;

PAUL, J .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE, 1961, 3 (04) :419-429

[3] EUKARYOTIC CHROMOSOME REPLICATION [J].

EDENBERG, HJ ;

HUBERMAN, JA .

ANNUAL REVIEW OF GENETICS, 1975, 9 :245-284

[4] INHIBITION OF DNA-REPLICATION BY ULTRAVIOLET-LIGHT [J].

EDENBERG, HJ .

BIOPHYSICAL JOURNAL, 1976, 16 (08) :849-860

[5] DNA-REPLICATION IN MAMMALIAN-CELLS - ALTERED PATTERNS OF INITIATION DURING INHIBITION OF PROTEIN-SYNTHESIS [J].

HAND, R .

JOURNAL OF CELL BIOLOGY, 1975, 67 (03) :761-773

[6] EFFECTS OF IONIZING-RADIATIONS ON DNA-REPLICATION IN CULTURED MAMMALIAN-CELLS [J].

MAKINO, F ;

OKADA, S .

RADIATION RESEARCH, 1975, 62 (01) :37-51

[7] ORGANIZATION OF REPEATED NUCLEOTIDE-SEQUENCES IN REPLICONS OF MAMMALIAN DNA [J].

MATTERN, MR ;

PAINTER, RB .

BIOPHYSICAL JOURNAL, 1977, 19 (02) :117-123

[8] X-RAY-INDUCED INHIBITION OF DNA-SYNTHESIS IN CHINESE-HAMSTER OVARY, HUMAN HELA, AND MOUSE L-CELLS [J].

PAINTER, RB ;

YOUNG, BR .

RADIATION RESEARCH, 1975, 64 (03) :648-656

[9] FORMATION OF NASCENT DNA-MOLECULES DURING INHIBITION OF REPLICON INITIATION IN MAMMALIAN-CELLS [J].

PAINTER, RB ;

YOUNG, BR .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 418 (02) :146-153

[10] GROWTH AND NUCLEIC ACID SYNTHESIS IN SYNCHRONOUSLY DIVIDING POPULATIONS OF HELA CELLS [J].

TERASIMA, T ;

TOLMACH, LJ .

EXPERIMENTAL CELL RESEARCH, 1963, 30 (02) :344-&

← 1 2 →