ADENYL CYCLASE AND HORMONE ACTION .3. CALCIUM REQUIREMENT FOR ACTH STIMULATION OF ADENYL CYCLASE

被引：118
作者：
BAR, HP
HECHTER, O
机构：
[1] Institute for Biomedical Research American Medical Association-Education, Research Foundation Chicago
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 35卷 / 05期
关键词：
D O I：
10.1016/0006-291X(69)90459-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
ACTH sensitivity of adenyl cyclase in mitochondrial and microsomal fractions from bovine adrenal cortex and in ghosts from rat fat cells can be abolished by the Ca complexing agent EGTA and restored by addition of Ca. EGTA also increases basal levels of cyclase activity in both systems and the degree of epinephrine stimulation in ghosts. Added Ca ion is inhibitory for basal and hormone stimulated activity in both systems. Ca may thus regulate 3′,5′-AMP formation both in the absence and presence of hormones. © 1969.
引用
收藏
页码：681 / &
相关论文
共 10 条
[1]  
BAR HP, IN PRESS
[2]   THE NEED FOR THE PRESENCE OF CALCIUM FOR THE STIMULATION INVITRO OF RAT ADRENAL GLANDS BY ADRENOCORTICOTROPHIC HORMONE [J].
BIRMINGHAM, MK ;
ELLIOTT, FH ;
VALERE, PHL .
ENDOCRINOLOGY, 1953, 53 (06) :687-689
[3]  
CHABAREK S, 1969, ORGANIC SEQUESTERING, P577
[4]  
HECHTER O, IN PRESS
[5]  
LOPEZ E, 1959, J BIOL CHEM, V234, P2254
[6]   EFFECTS OF ELECTROLYTES ON EPINEPHRINE STIMULATED LIPOLYSIS IN ADIPOSE TISSUE IN VITRO [J].
MOSINGER, B ;
VAUGHAN, M .
BIOCHIMICA ET BIOPHYSICA ACTA, 1967, 144 (03) :556-&
[7]   CYCLIC ADENOSINE MONOPHOSPHATE CA++ AND MEMBRANES [J].
RASMUSSEN, H ;
TENEHOUS.A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1968, 59 (04) :1364-+
[8]  
RODBELL M, 1967, J BIOL CHEM, V242, P5744
[9]   SOME ASPECTS OF BIOLOGICAL ROLE OF ADENOSINE 3',5'-MONOPHOSPHATE (CYCLIC AMP) [J].
SUTHERLAND, EW ;
ROBISON, GA ;
BUTCHER, RW .
CIRCULATION, 1968, 37 (02) :279-+
[10]  
TAUNTON OD, 1969, J BIOL CHEM, V244, P247
1