Small airways diseases, excluding asthma and COPD: an overview

被引：79

作者：

Burgel, Pierre-Regis ^{[1
]}

Bergeron, Anne ^{[2
]}

de Blic, Jacques ^{[3
]}

Bonniaud, Philippe ^{[4
]}

Bourdin, Arnaud ^{[5
]}

Chanez, Pascal ^{[6
]}

Chinet, Thierry ^{[7
]}

Dalphin, Jean-Charles ^{[8
]}

Devillier, Philippe ^{[9
]}

Deschildre, Antoine ^{[10
]}

Didier, Alain ^{[11
]}

Kambouchner, Marianne ^{[12
]}

Knoop, Christiane ^{[13
]}

Laurent, Francois ^{[14
]}

Nunes, Hilario ^{[15
]}

Perez, Thierry ^{[16
]}

Roche, Nicolas ^{[17
]}

Tillie-Leblond, Isabelle ^{[18
]}

Dusser, Daniel

机构：

[1] Univ Paris 05, Hop Cochin, AP HP, Serv Pneumol, Paris, France

[2] Univ Paris 05, Hop St France, AP HP, UMR INSERM S717, Paris, France

[3] Univ Paris 05, Hop Necker Enfants Malad, AP HP, Serv Pneumol Pediat, Paris, France

[4] Univ Bourgogne, CHU Bocage, Serv Pneumol, Dijon, France

[5] CHU Montpellier, Hop Arnaud Villeneuve, Serv Pneumol, Montpellier, France

[6] Univ Marseille, Hop Ste Marguerite, AP HM, Serv Pneumol,INSERM UMR 6020, Marseille, France

[7] Hop Ambroise Pare, AP HP, Serv Pneumol, Boulogne, France

[8] Hop Jean Minjoz, Serv Pneumol, Minjoz, France

[9] Univ Versailles St Quentin, UPRES EA 220, Hop Foch, Serv Pneumol, Suresnes, France

[10] CHRU Lille, Hop Jeanne Flandres, Serv Pneumol Pediat, Lille, France

[11] Univ Toulouse, Hop Larrey, Serv Pneumol, Toulouse, France

[12] Univ Paris 13, Hop Avicenne, AP HP, Serv Pneumol, Bobigny, France

[13] Univ Libre Bruxelles, Erasme Univ Hosp, Dept Chest Med, Brussels, Belgium

[14] Univ Victor Segalen Bordeaux 2, CHU Bordeaux, Serv Radiol, INSERM U 1045, Bordeaux, France

[15] Univ Paris 13, Hop Avicenne, AP HP, Serv Pneumol, Bobigny, France

[16] CHRU Lille, Hop Albert Calmette, Serv Pneumol, Lille, France

[17] Univ Paris 05, Hop Univ Paris Ctr, AP HP, Serv Pneumol, Paris, France

[18] CHRU Lille, Hop Albert Calmette, Serv Pneumol, Lille, France

来源：

EUROPEAN RESPIRATORY REVIEW | 2013年 / 22卷 / 128期

关键词：

Airway pathology; connective tissue disease; constrictive bronchiolitis; drug-induced lung disease; follicular bronchiolitis; immune deficiency;

D O I：

10.1183/09059180.00001313

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

This review is the summary of a workshop on small airways disease, which took place in Porquerolles, France in November 2011. The purpose of this workshop was to review the evidence on small airways (bronchiolar) involvement under various pathophysiological circumstances, excluding asthma and chronic obstructive pulmonary disease. Histopathological patterns associated with small airways disease were reviewed, including cellular and obliterative bronchiolitis. Many pathophysiological conditions have been associated with small airways disease including airway infections, connective tissue diseases and inflammatory bowel diseases, bone marrow and lung transplantation, common variable immunodeficiency disorders, diffuse panbronchiolitis, and diseases related to environmental exposures to pollutants, allergens and drugs. Pathogenesis, clinical presentation, a computed tomography scan and pulmonary function test findings are reviewed, and therapeutic options are described with the objective of providing an integrative approach to these disorders.

引用

页码：131 / 147

页数：17

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