Expression of transcription regulating genes in human preimplantation embryos

被引：0

作者：

Abdel-Rahman, Burae ^{[1
]}

Fiddler, Morris ^{[2
]}

Rappolee, Daniel ^{[1
,2
]}

Pergament, Eugene ^{[1
]}

机构：

[1] Northwestern Univ, Dept Obstet & Gynecol, Sect Reprod Genet, Med Sch,Prentice Womens Hosp & Matern Ctr, 333 E Super St,Suite 1566, Chicago, IL 60611 USA

[2] DePaul Univ, Sch New Learning, Chicago, IL USA

来源：

MOLECULAR HUMAN REPRODUCTION | 1995年 / 1卷 / 08期

关键词：

OCT4; OCT6; POU-domain; reverse transcriptase;

D O I：

10.1093/molehr/1.8.401

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Utilizing a sensitive reverse transcriptase-polymerase chain reaction (RT-PCR) assay system, the time course of mRNA expression of two transcription regulators, OCT4 and OCT6, was assessed in individual preimplantation human embryos. Examination of ova with three pronuclei and 1-cell through blastocyst stage embryos revealed that OCT4 mRNA was continuously expressed between the time of fertilization and 10+ cell stages, whereas OCT6 mRNA expression was not observed until the 10+ cell stage. The difference in the time of expression of OCT4 mRNA and OCT6 mRNA indicates that the two genes play differential roles in human embryogenesis. Nucleotide sequence homology for OCT4 and OCT6 among mammalian organisms supports the concept that genetic elements determining developmental events during embryogenesis are conserved in evolution.

引用

页码：401 / 406

页数：6

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