A BREAST-OVARIAN CANCER SUSCEPTIBILITY GENE MAPS TO CHROMOSOME-17Q21

被引：0

作者：

FEUNTEUN, J

NAROD, SA

LYNCH, HT

WATSON, P

CONWAY, T

LYNCH, J

PARBOOSINGH, J

OCONNELL, P

WHITE, R

LENOIR, GM

机构：

[1] INT AGCY RES CANC,ISO COURS ALBERT THOMAS,F-69372 LYON 08,FRANCE

[2] INST GUSTAVE ROUSSY,ONCOL MOLEC LAB,CNRS,URA 1158,F-94805 VILLEJUIF,FRANCE

[3] MCGILL UNIV,CTR HUMAN GENET,MONTREAL H3A 2T5,QUEBEC,CANADA

[4] MCGILL UNIV,DEPT MED,MONTREAL H3A 2T5,QUEBEC,CANADA

[5] MCGILL UNIV,DEPT ONCOL,MONTREAL H3A 2T5,QUEBEC,CANADA

[6] CREIGHTON UNIV,SCH MED,DEPT PREVENT MED,OMAHA,NE 68178

[7] UNIV UTAH,MED CTR,HOWARD HUGHES MED INST,SALT LAKE CITY,UT 84112

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 1993年 / 52卷 / 04期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.

引用

页码：736 / 742

页数：7