A BREAST-OVARIAN CANCER SUSCEPTIBILITY GENE MAPS TO CHROMOSOME-17Q21

被引：0
作者：
FEUNTEUN, J
NAROD, SA
LYNCH, HT
WATSON, P
CONWAY, T
LYNCH, J
PARBOOSINGH, J
OCONNELL, P
WHITE, R
LENOIR, GM
机构：
[1] INT AGCY RES CANC,ISO COURS ALBERT THOMAS,F-69372 LYON 08,FRANCE
[2] INST GUSTAVE ROUSSY,ONCOL MOLEC LAB,CNRS,URA 1158,F-94805 VILLEJUIF,FRANCE
[3] MCGILL UNIV,CTR HUMAN GENET,MONTREAL H3A 2T5,QUEBEC,CANADA
[4] MCGILL UNIV,DEPT MED,MONTREAL H3A 2T5,QUEBEC,CANADA
[5] MCGILL UNIV,DEPT ONCOL,MONTREAL H3A 2T5,QUEBEC,CANADA
[6] CREIGHTON UNIV,SCH MED,DEPT PREVENT MED,OMAHA,NE 68178
[7] UNIV UTAH,MED CTR,HOWARD HUGHES MED INST,SALT LAKE CITY,UT 84112
来源：
AMERICAN JOURNAL OF HUMAN GENETICS | 1993年 / 52卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.
引用
收藏
页码：736 / 742
页数：7
相关论文
共 14 条
[1]  
CLAUS EB, 1991, AM J HUM GENET, V48, P232
[2]   REPORT OF THE COMMITTEE ON METHODS OF LINKAGE ANALYSIS AND REPORTING [J].
CONNEALLY, PM ;
EDWARDS, JH ;
KIDD, KK ;
LALOUEL, JM ;
MORTON, NE ;
OTT, J ;
WHITE, R .
CYTOGENETICS AND CELL GENETICS, 1985, 40 (1-4) :356-359
[3]  
EASTON DF, 1993, AM J HUM GENET, V52, P678
[4]  
GO RCP, 1983, J NATL CANCER I, V71, P455
[5]   LINKAGE OF EARLY-ONSET FAMILIAL BREAST-CANCER TO CHROMOSOME-17Q21 [J].
HALL, JM ;
LEE, MK ;
NEWMAN, B ;
MORROW, JE ;
ANDERSON, LA ;
HUEY, B ;
KING, MC .
SCIENCE, 1990, 250 (4988) :1684-1689
[6]   GENETIC EPIDEMIOLOGY OF BREAST-CANCER IN BRITAIN [J].
ISELIUS, L ;
SLACK, J ;
LITTLER, M ;
MORTON, NE .
ANNALS OF HUMAN GENETICS, 1991, 55 :151-159
[7]  
LYNCH HT, 1981, GENETICS BREAST CANC
[8]  
MARGARITTE P, 1992, AM J HUM GENET, V50, P1231
[9]  
MARTINEZ M, 1991, AM J HUM GENET, V49, P1300
[10]  
NAROD SA, 1991, LANCET, V338, P82
12